The Pueblan Milk Snake (Lampropeltis triangulum campbelli) is renowned for its striking appearance, often featuring bands of red, black, and white or yellow that mimic the coloration of the venomous coral snake. This mimicry, known as Batesian mimicry, serves as a defense mechanism, deterring predators who mistake the non-venomous milk snake for its venomous counterpart. Interestingly, the rhyme "Red touch black, safe for Jack; red touch yellow, kills a fellow" helps differentiate between the two species in North America, although this isn’t foolproof outside of the region. The Pueblan Milk Snake’s vivid coloration and patterning have made it one of the most popular and recognizable subspecies among reptile enthusiasts.

In addition to its striking appearance, the Pueblan Milk Snake exhibits fascinating reproductive behaviors. In the wild, these snakes typically mate in the spring, with females laying clutches of 5 to 15 eggs. The eggs are usually deposited in hidden, warm, and moist environments, such as under logs or in leaf litter. The incubation period for the eggs ranges from 55 to 70 days, depending on environmental conditions. The hatchlings are born with the same distinctive coloration as the adults, although the intensity of their colors can vary. Pueblan Milk Snakes are also known for their adaptability, thriving in a variety of habitats, from dry forests to grasslands, which has contributed to their success both in the wild and in captivity.